DANSHEN PILL

DANSHEN PILL – A HEART PROTECTOR

INTRODUCTION

Danshen Pill is derived from a famous formula containing three important Chinese herbs: Danshen, Sanqui and Borneol. This formula is widely used in China to improve micro-circulation and shows significant efficacy. Furthermore, it has been successfully developed into a new product (Danshen Pill) by a well-known health dealer – TCM, which is famous for its advanced technology, excellent service and high quality products. Danshen Pill is your best choice to protect your heart.

MAIN INGREDIENTS

Danshen, Known as Salviae Miltiorrhizae

This is derived from the dry root and rhizome of Salvia miltiorrhiza, which belongs to labiate. In traditional Chinese medicine, Danshen has been used to prevent and treat heart conditions and strokes. Results from animal and human studies support these uses to some extent because Danshen is known to improve blood circulation and widen blood vessels, especially those around the heart.

Notoginseng root (San qi)

This is a frequently prescribed herb in Chinese medicine as a general tonic, or a medicine as a general tonic, or a medicine to tone and strengthen the entire system. One of China’s most famous herbalists said that the root was

“more valuable than gold”. Notoginseng is revealed to benefit for the heart and circulatory system. It appears to increase blood flow to the coronary arteries, which are the blood vessels that supply blood to the heart muscle. Heart disease usually results from blockages in the coronary arteries. Notoginseng also seems to increase the consumption of oxygen by the muscles in the heart. These actions have the effect of lowering blood pressure and regulating the rhythm of the heart.

Borneol

This is actually a compound derived from dryobalanops aromitaca, a tree that belongs to the teak family. The compound is formed by tapping the trunk of the tree, then cooling the substance and allowing it to harden into a clear crystalline substance. Borneol is used to promote drug biological availability.

PHARMACOLOGICAL EFFECTS

1.     Improve micro-circulation dysfunction induced by ischemia and reperfusion (I/R) through multiple mechanisms.

Reperfusion injury refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia. The absence of oxygen and nutrients from blood creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than restoration of normal function.

The efficient components in Danshen Pill are DLA and PNS, which are extracted from Saliva Miltiorrhiza and Radix Notoginseng. Their functions are listed as follows.

DLA (3,4-dihydroxyphenyl lactic acid)

v Block leukocyte’s adhesion on venules.

v Inhibit the production of peroxide on venule wall.

v Inhibit mastocyte degranulation in mesentery interstitium.

v Reduce plasma albumin leakage

v Counteract platelet aggregation.

v Lower blood viscosity

PNS (Panax notoginseng saponins)

v Block and dissociate leukocyte’s adhesion on blood vessel endotheliocyte.

v Inhibit mastocyte degranulation.

v Protect myocardial cells by decrease myocardial oxygen consumption.

v Anti-oxidation, anti-inflammation, protect vascular endothelial cells from damage and inhibit the information of artery atheromatous plaque.

v Suppress platelet aggregation and thrombosis

ACUTE AND CHRONIC TOXICITY TESTS

Ø Acute Toxicity Test

One group of mice was given Danshen Pill orally at the dose as much as 700 folds of adult human dosage for successive seven days. None of them died and LD50 is above 16.8g/kg. Another group was given hypodermically with injection of Danshen Pill for seven days and the dosage is equivalent to 350 times of adult human dose. None of them died and LD50 is above 8.4g/kg.

Ø Chronic Toxicity Test

50-fold adult human dosage of Danshen Pill was administered to rats orally once daily for 12 weeks successively. No adverse effects were observed including growth, hepatic and renal function, Hg and WBC count. Therefore, Danshen Pill is considered to be non-toxic and can be used for a long term.

2.     Improve Micro-Circulation

Compared with Doxium (Ca dobesilate), DPC shows a more remarkable improvement in sight vision, gray value of vision field, retinal micrangium tumor and small ecchymosis.

Features

v New preparation makes quick absorption possible.

v Well-selected materials makes high efficacy possible.

v A large number of laboratory and clinic researches ensure high safety and reliability.

Indications

v Heart pain, chest distress, panic and other symptoms related to coronary heart disease.

v Numbness, blurred vision and other symptoms related to poor microcirculation.

v High blood lipid, high blood pressure and other symptoms related to diabetes.

MICROCIRCULATION DYSFUNCTION

Hidden Risk of Heart Attack

Cardiovascular disease (CVD), principally heart disease and stroke, is the leading killer for both men and women among all racial and ethnic groups. Almost 1 million Americans die of CVD each year, which adds up to 42% of all deaths. Heart disease doesn’t just kill the elderly – it is the leading cause of death for all people aged 35 and older. Early medical detection and treatment is available, but the effectiveness of this in actually preventing heart attacks is questionable. Recent studies revealed a great majority of patients with CVD had microcirculation dysfunction at different degrees, which directly affect patients’ prognosis of heart attack.

What is microcirculation?

First of all, what is blood circulation?

The circulation can be pictured as blood travelling through the body in blood vessels. On average, we have about 5 litres of blood travelling through our circulatory system, delivering oxygen and nutrients to all parts of the body.

On its return route to the heart, the blood picks up carbon dioxide and waste products to be excreted. Arteries carry blood away from the heart, in large volume and under high pressure. Smaller arteries branching off are called arterioles and eventually lead to capillaries.

Capillaries are the tiniest of our blood vessels. Being small allows them to penetrate into every corner of the body, bringing oxygen and nutrients to the tissues and single cells.

Blood in the capillaries feeds the tissues before travelling away from tissue and organs, flowing into small veins called venules and then into larger veins carrying blood back to the heart.

Microcirculation is the vascular network lying between the arterioles and the venules, including capillaries, as well as the flow of blood through this  network. Or in other words: Microcirculation is the link between blood and single cell. By this link, tissue and single cells are supplied with oxygen and nutrients.

THE IMPORTANCE OF MICROCIRCULATION:

A better supply of blood and therefore oxygen and nutrients to a cell means:

The Cell functions better;

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The organ works better;

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All organs work better;

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The whole organism works better;

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Result

A person feels and is healthier!

MICROCIRCULATION DYSFUNCTION & DISEASES

The importance of abnormalities observed in the microcirculation of hypertensive subjects is being increasingly recognized. These micro vascular changes may be central to the development of end-organ damage brought about by hypertension, including ischemic heart disease.

The primary function of the microcirculation is to supply oxygen and nutrients to myocardial tissue, and it also has an important role in regulating coronary blood flow. Some 70-90% of the overall peripheral resistance of the circulatory system arises at the level of the microcirculation.

In hypertension, thickening of the micro vascular walls occur, with narrowing of the lumen, so that eventually the vessel is functionally occluded. The result is a reduction in the number of arterioles or capillaries in a given vascular bed. Such changes have been seen in the structure and density of the microvasculature of heart muscle, the conjunctiva and retina, and in the kidneys. In hypertension a vicious circle occurs, with an increase in blood pressure producing a rise in resistance in the microcirculation, leading to further elevation of blood pressure.

New techniques for exploring the coronary microcirculation have shown that micro vascular damage results in reduction of coronary vasodilator reserve, an important predictor of clinical deterioration and death. With studies showing that impairment of microcirculation occurs early in patients with hypertension, there would seem to be a need for new therapeutic perspectives in hypertension, concentrating on preventing or reversing changes to the microvasculature of affected organs.